doi: 10.1007/s10557-019-06915-8 90 VermaMKGoelRKrishnadasNNemmaniKVS
The concept of incretin effect was first proposed by Creutzfeldt in the 1970s ( 2 Physiology of incretins 2.1 Discoveries of GIP and GLP-1 The first incretin, GIP, was purified from canine intestinal extracts in the late 1960s ( + secretion ( Figure 1 Section A]
49 In contrast, female mice aged 6 weeks or older exhibited marked reductions in cortical, but not trabecular, bone following CR
3,4,109 This loading generates ground reaction forces and strain gradients that activate mechanosensitive bone cells, particularly osteocytes, via deformation, fluid shear, and piezoelectric signaling
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They block gastric emptying, decrease appetite, and reduces weight, which makes them particularly profitable in type 2 diabetic patients and obese patients
