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A case study of dilated cardiomyopathy in a family of dogs was linked to lower myocardial L-carnitine levels compared to healthy control dogs

Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]

Tsurusaki S, Tsuchiya Y, Koumura T, Nakasone M, Sakamoto T, Matsuoka M, et al

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It accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 500 deaths per year due to acute liver failure

N., Agharkar, A