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The SURMOUNT-5 authors hypothesize that GIP receptor expression in subcortical brain regions that regulate food intake doesn't fully overlap with GLP-1 receptor expression, which may explain the additive effect
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Survodutide (from Boehringer Ingelheim) is another dual agonist targeting GLP-1 and glucagon, but without the GIP component
Its also something your weight management or diabetes care team may recommend to help cover nutritional gaps in your diet
When initiating semaglutide in patients already taking insulin or sulfonylureas, consider reducing the doses of these medications to mitigate the risk of hypoglycemia
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