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This work was supported by the Discipline construction project of Guangdong Medical University (4SG22009G and 4SG23282G), the Funds for PHD researchers of Guangdong Medical University in 2021 (GDMUB2021021), and the Science and Technology Special Fund project of Guangdong Province in 2021 (2021A05199), the Guangdong Provincial Natural Science Foundation General Project (2022A1515012542), the Guangdong Basic and Applied Basic Research Foundation (No

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