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Retatrutide side effects reported in research have also included digestive symptoms
What are GLP-1 medications and how do they work Medically reviewed by Dr Sultan Linjawi, Endocrinologist & Diabetes Specialist January 2026 GLP-1 medications have become some of the most talked-about treatments in type 2 diabetes and for good reason
Glucose control The SURPASS studies enrolled populations that were similar in terms of baseline HbA1c levels, which ranged from 7.9 to 8.5% [2, 3, 59,60,61] and found a statistically significant reduction in HbA1c already at the 5 mg dose, demonstrating a greater efficacy of tirzepatide compared to placebo or active comparator [2, 3, 59,60,61]
That matters for labeling, standardized manufacturing, and formal FDA review of safety and efficacy
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