Pregnant individuals have better and safer options to manage their weight
The GLP-1 drug participants had no progression of motor symptoms (-0.04), and the 3.04 worsening in the placebo group (difference between the two arms=3.08) is just short of what is considered clinically meaningful (3.5)
Many of these agents affect more than one of the putative pathogenic targets
The main mechanisms include: The strongest outcomes usually occur when GLP-1 medication is combined with protein-focused nutrition, resistance training, walking, sleep improvement, hydration, stress management, and regular physician monitoring
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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]
