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Trends Neurosci 24:411416 Mondal D, Pradhan L, Ali M, Agrawal KC (2004) HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants
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To account for the continuing degeneration and atrophy in later stages, in the face of waning adaptive inflammation as the disease progresses, it has been proposed that the inflammation becomes trapped behind the bloodbrain barrier, continuing to damage the CNS, but now being inaccessible to peripherally-administered immunosuppressants