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Muscle Loss Risk Increases (Major Concern) GLP-1 users already risk: low protein intake low calorie intake rapid weight loss lean tissue loss Add nightly alcohol and you get: impaired muscle protein synthesis lower testosterone (men) reduced growth hormone increased cortisol reduced recovery Result: More muscle loss Less fat loss Softer look Slower metabolism This is one of the biggest physiological downsides

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 Correlation analysis among clinical indicators, specific metabolites, and proteins

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Phentermine: This can result in about 5-10% weight loss over a short-term period

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