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However, now that the FDA has approved Wegovy for an additional indication (lowering cardiovascular risk in adults with heart disease and obesity or overweight), coverage may expand for Wegovy

However, this broader action means a higher chance of gastrointestinal side effects early on

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Int J Mol Med 14:207215 Biernacka BA, Koceak P, Owczarek AJ, Choreza P, Puzianowska KM, Markuszewski L, Madej P, Chudek J, Olszanecka GM (2022) SHBG Prediction of insulin resistance and impaired fasting glucose based on Sex Hormone-Binding Globulin (SHBG) levels in polycystic ovary syndrome

Because these patients may already experience digestive symptoms related to altered bile flow, distinguishing medication-related side effects from pre-existing issues requires careful monitoring during titration