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The underlying molecular mechanism is that tumours driven by BRAF V600E exhibit high extracellular signal-regulated kinase phosphorylation, which activates the mitogen-activated protein kinase (MAPK) signalling pathway, leading to unregulated cell proliferation and a poor prognosis [72]

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High-intensity statins show the largest signal, and the effect appears dose-dependent

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Arthroscopy 28 , 429439 (2012)

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