51 This evidence suggest that Danuglipron demonstrates potential for glycemic control and weight reduction in T2DM with an acceptable safety profile
In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time
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Apovian points out, theres nothing shabby about the kind of weight loss you get with semaglutide and tirzepatide
These potential side effects, along with alopecia, need to be carefully weighed up against the health benefits for each individual patient
Phase 2 trials reported mean systolic blood pressure reductions of approximately 46 mmHg in higher-dose groups, alongside a modest increase in heart rate consistent with the GLP-1 drug class
