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Vitamin B12 can then be absorbed into the bloodstream via endocytosis in the distal ileum, or by passive diffusion in the absence of intrinsic factor.2 Pernicious anemia (an autoimmune disease) affects the gastric mucosa, leading to destruction of parietal cells and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption and eventually deficiency

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JCI Insight 2 , e88735 (2017)

Epigenetic Regulation Studies: Allows examination of methylation dynamics influenced by NNMT modulation

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IM B12 shots every month completely changed my energy levels. u/autoimmune_warrior After gastric bypass surgery, I couldnt absorb oral supplementsB12 injections have kept my levels stable