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We suggest semaglutide lowers body weight by direct interaction with diverse GLP-1R populations and by directly and indirectly affecting the activity of neural pathways involved in food intake, reward, and energy expenditure
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(2025) found that patients without diabetes lost an average of 7.0% of their weight over 6 months if treated with tirzepatide compared to 3.4% if treated with semaglutide, but the study did not analyse dose or titration schedules [9]
114 This is inconsistent with findings that inhibiting ferroptosis promotes EMT in other tumors
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