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Fine lines and wrinkles develop due to a combination of: Collagen and elastin loss with age Repeated facial expressions (smiling, frowning, squinting) Sun exposure (photoaging) Dehydration and impaired skin barrier Lifestyle factors (stress, sleep, nutrition) Over time, these lead to visible changes in skin texture, elasticity, and volume

The affected areas are usually darker than the surrounding skin

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This modulation of apoptotic signaling pathways indicates metformins potential as an effective cancer treatment (60)