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This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al

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Conversely, nutritional therapy involving the administration of beneficial bacteria such as Bifidobacteria, Lactobacillus , and probiotics can attenuate HPA axis activity, restore normal ACTH, CORT, and BDNF levels, and exert an antidepressant effect (Sun et al., 2022)

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