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FDA approval is the most significant regulatory difference

GLP-1 medications are approved for adults who have a body mass index (BMI) of 30 or higher, or a BMI of at least 27 plus a weight-related medical condition, such as the following: Type 2 diabetes High blood pressure High cholesterol Obstructive sleep apnea Cardiovascular disease that increases the risk of heart attack or stroke MASH, or metabolic dysfunctionassociated steatohepatitis, a form of liver inflammation Avlin Imaeda, MD, PhD, a Yale Medicine gastroenterologist who is board-certified in obesity medicine, notes that qualifying for the medication based on heart disease aloneoften necessary for insurance coveragecan be challenging

doi: 10.1056/NEJMoa2206038 201 ArmstrongMJGauntPAithalGPBartonDHullDParkerRet al

Some patients may have compensatory mechanisms that maintain hunger signals despite GLP-1 receptor activation

What side effects are most important to watch for with Rybelsus

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