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Double knockout animals for both GIPR and GLP-1R (DIRKO) showed in cortical bone the same bone alterations seen in single GLP-1R KO animals [45]

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Given its complexity, effective obesity management necessitates a multidisciplinary, individualized approach that combines nutritional and behavioral interventions, physical activity, pharmacological therapies, and metabolic-bariatric surgery when indicated

Hensley et al., 2003