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Methods Study design, site and patients This analysis used real-world data from patients attending a metabolic health clinic (NOVI Health) in Singapore, a city-state in tropical Southeast Asia with a population of 6.04 million [16]

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We found low levels of heterogeneity when analysis was done in individual brain regions, However when all areas were combined in the analysis the heterogeneity was much higher (I 2 of 72.18)

Nature 457(7230):687693 Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N et al (2002) Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

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