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Upon GPCR activation, adenylyl cyclase produces cAMP, which triggers transcriptional activation of a response element (RE), leading to NanoLuc Luciferase expression and bioluminescent signal

Julius, U., Tselmin, S., Weigmann, I., & Tiano, L

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Nordstrm, HPA axis hyperactivity and cardiovascular mortality in mood disorder inpatients, Journal of Affective Disorders 116 (2009) 8892

But those same biological systems interact with the dopamine networks involved in ADHD