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Before obvious clinical symptoms appear in AD patients, increased BBB permeability occurs in many brain regions, including the hippocampus, cortex, deep gray matter, and white matter by Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) [146,147,148,149]

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2023;189(1):G142

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In this context, the subcutaneous LDopa infusion pump could offer an intermediate approach between the two conventional administration routes of LDopa, potentially mitigating some side effects

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