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References Rucker JJH, Iliff J, Nutt DJ

(2019) demonstrated that noise-induced hearing loss in mice is associated with elevated proinflammatory cytokines and microglial activation in the primary AC, and that genetic knockout of TNF- or pharmacological depletion of microglia prevented the development of tinnitus-related behavioral phenotypes

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Each model should be interpreted according to its own endpoint, biological assumptions, and translational limitations