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Dpp4 EC/ (BMT) mice exhibited an approximately 25% decrease in plasma DPP-4 activity and an approximately 2.5-fold increase in plasma active GLP-1, without differences in body weight or levels of fasting TG, consistent with the importance of DPP-4 expression in endothelial cells (Figure 2E)

2 : EXECUTIVE SUMMARY 21 2.1

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berghei ANKA 507cl1 gst locus, using primers detailed in Supplementary Table S2

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Clinical trials have demonstrated improvements in liver injury through normalization of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels following GLP-1 treatment