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Excess body weight (BW) is a well-established risk factor for type 2 diabetes (T2D), cancer, cardiovascular diseases (CVD), asthma, gallbladder disease, osteoarthritis, and chronic back pain, underscoring its profound impact on both individual and public health [6]

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However, these models are expensive, requiring special training to operate and are difficult to use in high-throughput experiments

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A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention

As well as endogenous GLP-1,GLP-1 receptor agonists also have numerous other effects such as promoting weight loss, deceleration of gastric emptying, lowering blood pressure (systolic and diastolic), and lowering total cholesterol (10, 2729)