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According to the SmPC and STEP clinical trials, these include: Nausea (affecting approximately 40-45% of patients) Vomiting (approximately 15-25% of patients) Diarrhoea (affecting approximately 25-30% of users) Constipation (approximately 20-25% of patients) Abdominal pain and bloating Gastro-oesophageal reflux For individuals taking oral anti-epileptic medications , severe or persistent vomiting could theoretically reduce drug absorption, potentially affecting seizure control

Semaglutide has also been shown to be associated with superior adherence compared to other GLP-1 RAs [23, 24]

Yes, switching is a legitimate strategy

In both in vitro and in vivo conditions, melatonin inhibits the cell cycle to provide a variety of anti-proliferative effects

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Berg JK, Shenouda SK, Heilmann CR, Gray AL, Holcombe JH