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Lancet Gastroenterol Hepatol Mantelmacher FD, Fishman S, Cohen K et al (2017) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis

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It affects a significant number of users, and for some, it can be disruptive

In the United States, a combination product containing topiramate and phentermine (Qsymia) is approved for obesity management, but this combination is not licensed by the MHRA for use in the UK

This effect is dose-dependenthigher doses increase the likelihood of diarrhea, especially during the first 48 weeks of treatment