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The GCL enzyme is a heterodimer formed by two subunits: the heavy subunit or glutamate cysteine ligase catalytic subunit (GCLC, 73 kDa) and the light subunit or glutamate cysteine ligase modulating subunit (GCLM, 30 kDa)

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The concern escalates in two scenarios

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The novel conclusions generate new hypotheses regarding serine-folate-glycine one carbon and serine-phospholipid metabolic pathways, elevation of end products of catabolic pathways, shifts in folate, thiamine and other vitamins with exercise, and changes in sphingomyelins that may indicate myelin and white matter dysfunction in ME/CFS