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On February 6, FDA announced its intention to take decisive enforcement action against non-FDA-approved compounded GLP-1 drugs, specifically identifying restrictions on GLP-1 active pharmaceutical ingredients (APIs) used in mass-marketed compounded products

Similarly, a 2019 meta-analysis published in Obesity Reviews concluded that weight cycling increases the risk of cardiometabolic disease, systemic inflammation, insulin resistance, and psychological distressespecially among women (Eun-Jung Rhee, 2017)

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The new launch has caught the attention of President Joe Biden, who said in a statement that it is "a welcome first step for American families struggling to access these drugs," but added that it is "critical that drug companies lower their prices across the board."