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(Epub ahead of print.) Mattson TV (2018) Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
It is designed to be taken in low doses daily, before switching to a higher weekly dose around day 11
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The core mechanisms underlying these protective effects involve inhibition of oxidative stress and inflammatory pathways (e.g., regulation of NF-B, Nrf2, AGEs/RAGE/Nox4), reduction of apoptosis and necrosis, enhancement of endogenous antioxidant defenses (e.g., increased antioxidant enzyme activity and Hsp70/90 expression), and improvement of BTB integrity (61, 88)
A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients