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It also modulated gut microbiota composition, lowering the Firmicutes/Bacteroidetes ratio and improving intestinal barrier function by increasing expression of tight junction proteins such as ZO-1, occludin, and claudin-1

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Although BALB/c mice do not naturally develop AD (Mancuso et al., 2019), their genetically stable background makes them an excellent model for isolating the effects of genetic modifications, environmental factors, or therapeutic interventions on AD pathology (Balietti et al., 2023)

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