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Its also prescribed off-label for weight management due to its effect on appetite and insulin regulation

The commenters noted that in real dollar terms, the flat rate payment for NTIOLs has significantly lagged the overall economic inflation rate, with consumer inflation increasing by 138.6 percent since 2010 and manufacturing costs rising due to labor inflation and increased material costs

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Pregnant or breastfeeding women, people with severe health conditions like chronic liver or kidney disease, and people with known allergies to any components of the injections should avoid them

Martin Hamburger filed a proposed class action against the insurer and pharmacy benefit manager in September 2025 in the US District Court for the District of Columbia, alleging the exclusion amounted to an illegal denial of benefits and breach of fiduciary duty under ERISA

Emerging therapies, by targeting these pathways, offer hope for more effective and long-lasting solutions