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These mechanisms are worth mentioning since if the results in this latest correspondence in the NEJM are indeed replicated, there is a large difference if these effects are occurring either a) Because pancreatic beta cells are dying less b) Because pancreatic beta cells are growing back c) Because pancreatic beta cells are not being targeted by the immune system anymore If replicated, I find a) and b) to be the most likely reasons

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"This was very concerning and something we needed to address and communicate to the public like we are doing right now," Harter said

Once reconstituted, the liquid solution is sensitive to thermal degradation and must be continuously refrigerated at 4C