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Meanwhile, GnRH antagonists such as relugolix and linzagolix rapidly suppress ovarian hormone production, leading to fibroid size reduction and symptom relief, with ongoing studies assessing their long-term safety and optimal dosing strategies

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We, therefore, inhibited autophagy in both vitiligo melanocytes and fibroblasts using 3-methyl adenine (3-MA) that blocks the activity of hVps34, which is essential for phosphatidylinositol 3-phosphate production (PI3P) during the early stages of autophagosome assembly 24