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In the cardiovascular system, GLP-1R is known to exist not only on cardiomyocytes and endothelial cells, but also in the autonomic nervous system, Figure 3 suggests that GLP-1R may have direct and indirect effects on the heart and blood vessels

Though GLP-1RAs are increasingly being prescribed for off-label uses, more than nine in 10 of the physicians surveyed across all specialties have prescribed a GLP-1RA medication for weight loss

The active receptor targets are the same, but the formulation, source, and regulatory pathway differ

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These cardiovascular factors increase the patients overall risk of mortality and morbidity due to potential cardiovascular events such as a myocardial infarction or stroke 1

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