glp-1/gip agonist Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research GI Adverse Effects of Glucagon-Like

Epilepsia 41, S9S13

Stovell MG, Helmy A, Thelin EP, Jalloh I, Hutchinson PJ, Carpenter KLH

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Nobiletin showed no obvious cytotoxicity in vivo (0.05% dietary concentration for 320 weeks) or in vitro (effective concentration 40 M), and cells resumed normal growth after withdrawal, with safety superior to existing chemotherapeutic agents (Goh et al., 2019)

Whether this finding can be replicated in future studies, and what significance it holds for the broader understanding of GLP-1R agonisms effects on food preference, remains to be determined

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