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Wharton S, Liu A, Pakseresht A, Nrtoft E, Haase CL, Mancini J, Power GS, Vanderlelie S, Christensen RA

These multifaceted metabolic effects position dual GLP-1/GIP receptor agonists as superior therapeutic candidates for MASLD, especially in patients with coexisting obesity and T2DM, where dysregulated glucose and lipid metabolism drive the progression of the disease

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320 Interestingly, the GIPR-deficient mice had increased oxygen consumption and respiratory quotient indicating that they used the excess fat to generate ATP