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Iacobazzi V, Infantino V, Castegna A, Andria G

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This is critical for generating energy in high-demand cells found in the nerves, heart, and muscles, ensuring they have the fuel needed for optimal function

Studies in rats and mice show that melatonin has toxic effects if given at extremely high doses (more than 400 mg/kg), but this is tens of thousands of times more than the recommended dose for treating sleep disorders, which varies between 2-10 mg

Hepatic dysfunction is described in patients during episodes of metabolic derangement [28] and can be fatal