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The antacids represent one of the most prescribed categories of drugs worldwide: the interference with thyroxine bioavailability has been described for proton pump inhibitors and calcium carbonate ( in vitro : indeed, it appears to bind thyroxine in a dose-dependent manner when medium pH is two

L., Applebaum, J., Chicchi, G

Willards team, in JCI Insight, calls it a biased, imbalanced agonist, which is a fancy way of saying it leans on the GIP receptor while behaving like a plain GLP-1 copy at the GLP-1 receptor

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PMID 17193224