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This leads to reduced hunger and increased feelings of fullness , which can result in decreased caloric intake

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This speculation derived from the discovery by Stephen Bloom in London that injection of GLP-1 into the intracerebral ventricles strongly inhibited feeding in fasted rats

Ozempic is not licensed in the UK for weight loss, but Wegovy is

The 4-OH of hydroxy benzylidene ring from two interactions with the imidazole group of His85 (2.03 ) and His263 (2.7 )