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Additionally, islets isolated from individuals with type 2 diabetes exhibit decreased DPP-4 activity in order to preserve GLP-1 secretion in culture, further implicating a functional role of endogenous islet GLP-1 in diabetes [29]

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Kennedys potential plan here is essentially a jailbreakforcing the agency to move them back into the Category 1 safe harbor where compounding is permitted while under evaluation It has also been practice that category shifts required new data, generally meaning actual good clinical trial data

Protein quantification was based on the summed peak intensities of all peptides assigned to a given protein