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In the SURMOUNT-5 trial, which directly compared the two medications, Mounjaro 15 mg produced 20.2% weight loss, while Wegovy 2.4 mg produced 13.7% over 72 weeks

Recent tests and corrections are shown below when available

Studies published in JAMA Network confirm that bariatric surgery significantly reduces the risk of heart failure, stroke, and hypertension in obese individuals with Type 2 diabetes

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Retatrutide is a novel triple-agonist peptide developed by Eli Lilly, targeting GIP, GLP-1, and glucagon receptors, showing significant promise in clinical trials for obesity and type 2 diabetes due to its potent effects on appetite, energy expenditure, and glycemic control

But the enteric nervous system, which governs gut motility through a dense network of neurons that neuroscientists sometimes call the second brain, is not built to sustain that kind of chronic, pharmacological override