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Several preclinical and animal studies have suggested that GLP-1RAs may have neurotrophic and neuroprotective effects, by reducing neuroinflammation, oxidative stress, apoptosis, and mitochondrial dysfunction and by promoting the growth and repair of neural cells, potentially enhancing cognitive functions [73,74,75]

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This large study found that their side effects are consistent with what we already know, giving us even more confidence in their use. In Australia, semaglutide sold as Ozempic has rapidly grown in use since it gained social media popularity as a weight-loss drug, with off-label prescribing prompting ongoing shortages now expected until December 2025

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10.3389/fnins.2021.646678 77

When GPx3 was correlated to age, we also found a poor correlation exists between these two variables (Pearson correlation coefficient (r) = 0.17, p = 0.02), indicating that age is not strongly influencing the differences of GPx3 abundance in this sibling cohort (Supplementary Fig