Cusick SE, Barks A, Georgieff MK
Most people with gallstones (about 80%) never experience symptoms
Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients
Consequently, the definition of treatment success is also expanding beyond headline weight loss achieved, to include the full spectrum of patients therapeutic needs, for example: Effective and durable weight maintenance Managing co-morbidities along the cardio-metabolic-renal spectrum Preserving muscle mass Tolerability, safety Convenience, e.g., delivered via oral therapies and/or less-frequent dosing * Including diabetes, ASCVD, Afib, HTN, PAH, dyslipidaemia, heart failure, PAD, MI, stroke, cardiovascular disease, CKD Source: IQVIA LAAD
The few medications traditionally prescribed for them are often minimally effective, and bariatric surgery is invasive and risky
The article explains that transdermal estradiol patches bypass hepatic first-pass processing, which reduces changes to lipids and clotting factors compared with oral estrogen, so the transdermal route generally pairs more safely with GLP-1 medications
