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Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

The modifications shall be devolved to obtain the stable function of studied enzyme activity under saturation conditions [15] Only in this instance the time course of absorbance of NADPH at 366 nm describes the real kinetic behaviour of GP catalized redox reaction

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