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Sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, maximum likelihood, and RAPS (Supplementary Table S4) showed consistent directionality of effects for schizophrenia, anxiety disorders, and autism

Instead, it is commonly used as a systems-level neuromodulatory probe to study interactions between sleep architecture, stress signaling, and neuroendocrine regulation

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Oxygen supplementation can have a similar stabilizing effect on the ventilatory drive, as increases in the partial pressure of oxygen can lower the bodys peripheral chemosensitivity and downregulate chemical loop gain [82]