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Furthermore, oxidative stress activates the release of HMGB1 signal transduction in keratinocytes by decreasing the level of melanogenetic molecules (including gp100) and inducing apoptosis

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However, the levodopa equivalent daily dose at onset of dyskinesias in the entacapone group of STRIDE-PD was higher than in the EPSILON study, which may explain the different dyskinesia outcome

doi:10.1002/jnr.20877 Zhang R, Zhang H, Zhang Z, Wang T, Niu J, Cui D, Xu S (2012) Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro