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Notably, the LASSS-pretreatment displayed greater preventive effect on nitration of Y198 compared to Y250, as revealed by re-probing with anti-nitroY198 and Y250-HGF mAbs (Figure 2b, first and second rows, lanes 2 and 3

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According to preliminary results, ferroptosis may be involved in balancing the synovium growth and death

The compound demonstrates a remarkable capacity to regulate immune cell function, modulating macrophage and neutrophil activities

Additionally, a CRISPR suppression screen and ferroptosis-resistant cell line investigation revealed the deactivation of ACSL4 as a critical mechanism for inhibiting ferroptosis in various conditions