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L cell secretagogues Stimulation of GLP-1 secretion from enteroendocrine L cells is another approach that may be able to realise the therapeutic potential of GLP-1, perhaps in combination with DPP-4 inhibition to prevent the inactivation of the GLP-1 released

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The deficit from the peptide plus training stress plus life stress plus insufficient sleep creates a feedback loop: poor sleep raises cortisol, which disrupts sleep further, which raises cortisol more