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Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models

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Sahni N, McGrail DJ, Garnett J, Yin J, Dai H, H Shih DJ, Peng G, Menter D, Yates MS, Kopetz S , Lu K, Broaddus R, Mills GB, Lin SY

However, data generation mechanisms differ substantially between RWD and RCT, and systematic differences are probable