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This occurs because semaglutide influences brain regions that regulate body temperature and increases metabolic activity

While short- and medium-term impacts have been looked at, studies to determine whether there are long-term side effects will be necessary, according to Manning

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We have decades of evidence showing that chronic manipulation of enteric signaling (i.e., telling different sections of the digestive tract what to do and when), whether through opioids, supplements, or antidepressants, produces adaptations that outlast the drug itself

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