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For instance, cyclic-AMP (cAMP) is one of the upstream signals that regulate both mitochondrial biogenesis and mitophagy

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The gut mucosal immune system features a multilayered firewall of epithelial cells, mucus, secretory IgA, and immune cells (dendritic cells, T lymphocytes), limiting microbial access to gut-associated lymphoid tissue (GALT) and preventing systemic immune activation [97,98,99]

The gap between animal research and proven human therapies remains significant

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